Theme V Replacement and Reduction in Basic Research
V-1
Novel methodologies and their potential in vitro application for drug development and safety assessment

This session will provide the opportunity to examine some of the emerging approaches being used for drug development and safety assessment (e.g. stem cells, in vitro receptor assays, genomics and proteomics approaches, computer modeling of molecules and biological systems).

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V-2
Systematic reviews of animal experiments

This session will focus on why systematic reviews of animal experiments are urgently needed, how they need to be done, and the hurdles that need to be overcome to ensure that the Three Rs are being implemented in research studies.

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V-3
Cell culture and tissue engineering

This session will provide an opportunity to discuss the potential for tissue engineering to be used in basic research and to contribute to the development of pharmaceuticals and novel chemical solutions.

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V-4
Refinement and Reduction in the use of genetically-engineered animals

The generation and use of genetically-engineered animals continues to increase. Although the focus has typically been on the implementation of refinement strategies, this session will examine some of the newer technologies that can be employed to replace or reduce the numbers of genetically-engineered animals brought into being.

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V-5
Developments in stem cell research as the basis for sustainable availability of differentiated human cells and tissues

Stem cell research offers the possibility to use models that have greater relevance for human medicine. This session will focus on the challenges that need to be overcome in order to fully incorporate stem cells as a viable replacement / alternatives tool in basic research.

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V-6
Animal reduction through the better use of mechanistically-based translational animal disease models

While it still remains the case that animals continue to be used as disease models there are approaches that can be used to ensure that the most appropriate animal model is employed. This session will include an examination of less symptomatic models, human pathways-based animal disease models, and the use of surrogate endpoints.

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V-7
Additional Session: Relevance, Reproducibility and Robustness - the other Three Rs important to science and animal welfare

This session will outline how the provision of better scientific approaches and platforms that lead to relevance, reproducibility and robustness of the models, contributes to advancement in the development of human therapeutics while incorporating the 3Rs.

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V-8
Additional Session: Presentation of Go3R search engine with hands-on trials on PC terminals

Go3R, the first knowledge-based search engine for alternative methods to animal experiments, was developed to enable scientists and regulatory authorities involved in the planning, authorisation and performance of animal experiments to determine the availability of 3Rs relevant information from PubMed in a fast and comprehensive manner. This workshop provides hand-on training to use the Go3R Search Engine to speed up and improve the procedure of information retrieval for alternative methods.

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V-9
Additional Session V-9: Improving reporting of animal-based research

This session will highlight recent efforts to improve the reporting of animal research from the NC3Rs and from the US National Academy of Sciences' Institute for Laboratory Animal Research (ILAR), and provide a platform for discussion about the pros and cons of reporting guidelines.

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